A231801
Mentor: Dr. Aaron Lucius, Department of Chemistry
Postdoctoral Position in Biophysical Chemistry
Department
Chemistry
www.uab.edu/chemistry
Mentor
Aaron L. Lucius, Ph.D.
Professor
University of Alabama at Birmingham
Department of Chemistry
Chem 292
1530 3rd Ave S
Birmingham, AL 35294-1240
Office: 205-934-8096
Fax: 205-934-2543
E-mail:
Job Description: A postdoctoral position is available to investigate the chemical kinetics of nitration. This work will employ transient state and steady state kinetic techniques to examine the mechanisms of enzyme catalyzed nitration of proteins. The focus of this research is to determine the mechanisms of natural decomposition of peroxynitrite and enzyme catalyzed decomposition as well as enzyme catalyzed nitration. The work will involve using rapid mixing kinetic approaches including fluorescence/absorbance stopped-flow and chemical quench-flow, and the high-level data analysis techniques required to analyze the results. In addition, there will be a need to overexpress proteins containing unnatural amino acids and isolate those proteins using standard methods including liquid chromatography techniques. Other techniques employed in the lab may become important including fluorescence titrations, isothermal titration calorimetry, differential scanning calorimetry, analytical ultracentrifugation.
Job Requirements: A Ph.D. is required in biochemistry, molecular biophysics, physics, chemistry or related discipline within the last five years. Experience or training with isolating and handling recombinant proteins from bacterial systems, preferred. Candidates must have demonstrated proficient performance in research and proven their ability to work independently and to use quantitative and qualitative research methodologies to capture and interpret data, give great care and attention to detail, report research results and to communicate their work effectively. Candidates must have excellent written and verbal communication skills in English. Qualified candidates should send their CV, including contact information for three references to
About our Postdoc Office
UAB is committed to the development and success of outstanding postdoctoral scientists. Here at UAB, nearly 300 postdoctoral fellows are training currently in a variety of disciplines. Competitive postdoc awards are available including internships, grant incentives, funds to enhance education and collaboration outside UAB, and teaching opportunities at local universities. There is also a Postdoc Research Day with monetary awards. The Office of Postdoctoral Education strongly encourages UAB research mentors to follow the National Research Service Award stipend level guidelines, and postdoctoral scholars qualify for health, life, and other insurances. They also have the right to participate in the university’s 403(b) program and enjoy vacation, sick leave, maternity/paternity leave, and other benefits.
About the University
The University of Alabama at Birmingham (UAB) is a research university and academic health center that discovers, teaches, and applies knowledge for the intellectual, cultural, social, and economic benefit of Birmingham, the state, and beyond. UAB is internationally renowned for its intensely collaborative culture that has — for more than five decades — produced breakthroughs in education, health care, research, and service. UAB was ranked #1 in the United States, and in the top 10 worldwide, in the Times Higher Education World University Rankings, 2018 Young University Rankings.
Spanning more than 100 city blocks, UAB is the state of Alabama’s largest single employer with nearly 28,000 employees and has an annual, state-wide economic impact of $12.1 billion. U.S. News & World Report’s 2022 “America’s Best Graduate Schools” ranks 16 UAB graduate programs among the nation’s top 25 and eight UAB specialties were ranked among the nation’s top 50 in the magazine’s 2022-2023 Best Hospitals report. UAB research grants and awards are at a record high, totaling $715 million in FY22 — a 50% increase over the past five years. UAB ranks 33rd among all universities in federal research funding and 17th among public universities. UAB's NIH funding continues to grow among peer institutions in the Southeast and beyond, with the university ranking 25th among all universities in NIH funding and 11th among public universities.
UAB is an Equal Opportunity/Affirmative Action Employer committed to fostering a diverse, equitable and family-friendly environment in which all faculty and staff can excel and achieve work/life balance irrespective of, race, national origin, age, genetic or family medical history, gender, faith, gender identity, and expression as well as sexual orientation. UAB also encourages applications from individuals with disabilities and veterans.
For more information on Equal Opportunity and Affirmative Action at UAB, visit the UAB Office of Diversity, Equity and Inclusion opens a new website, call (205) 934-8762, or contact the office at 701 20th Street South, AB 336, Birmingham, AL 35294-0103.
